Rome’s business environment is undergoing significant transformations, marked by the decline of traditional retail outlets and the emergence of innovative entrepreneurial ventures. This shift reflects broader economic trends and the city’s adaptive strategies.
Decline of Traditional Retail
Recent data indicates a substantial reduction in traditional retail businesses. Between 2019 and 2025, the commerce sector experienced a 22.9% decrease, with approximately 24,000 businesses closing. The clothing sector was particularly affected, witnessing a 33% decline over six years. Factors contributing to this downturn include escalating rental costs, intensified online competition, and diminished consumer spending power. Notably, between 2024 and 2025, 1,900 neighborhood shops ceased operations, underscoring the challenges faced by brick-and-mortar establishments.
Emergence of Entrepreneurial Initiatives
In response to these challenges, Rome has seen a surge in entrepreneurial programs aimed at revitalizing the local economy:
Roma Rigenera Impresa
Launched by the Assessorato alle Attività Produttive e alle Pari Opportunità, this initiative focuses on fostering new businesses in areas like Corviale, Tor Bella Monaca, and Santa Maria della Pietà. The program offers comprehensive support, including training, legal and financial assistance, and networking opportunities, to stimulate local entrepreneurship.
SpinOut! R&D Entrepreneurship Program
Managed by Zest under the Rome Technopole’s Flagship Project 7, SpinOut! aims to transform health and bio-pharma research projects into high-potential startups. The program provides intensive training, mentorship, and market validation, leveraging AI platforms like Aipermind to accelerate development.
RBS4Entrepreneurship
The Rome Business School’s RBS4Entrepreneurship program supports aspiring entrepreneurs through training, mentorship, and incubation services. Since its inception, it has engaged nearly 500 students from 57 countries, fostering a diverse and dynamic startup ecosystem.
Impact of Infrastructure on Local Economy
Infrastructure developments, such as the expansion of Rome’s metro system, have positively influenced the local economy. A study on the Metro C line revealed a significant increase in economic activities in areas with improved accessibility, highlighting the role of public transport investments in economic revitalization.
In conclusion, while traditional retail sectors in Rome face considerable challenges, the city’s proactive initiatives and infrastructure developments offer promising avenues for economic renewal and growth.

